Why is Iron Bisglycinate better? Superior absorption compared to other iron forms

Why is Iron Bisglycinate better? Superior absorption compared to other iron forms

Iron is an essential mineral for our bodies. It plays a vital role in various physiological processes, including oxygen transport, DNA synthesis, and energy production. However, not all iron supplements are created equal. Different forms of iron have varying degrees of bioavailability, which means they aren't all absorbed by the body with the same efficiency. Moreover, some can lead to unpleasant side effects like constipation and nausea.

Enter iron bisglycinate – a form of iron that has emerged as the superior choice for supplementation. But why?

Superior Absorption

When it comes to choosing an iron supplement, absorption is paramount. A study published in the 'Journal of Trace Elements in Medicine and Biology' found that iron bisglycinate was more easily absorbed than other commonly used forms of iron, such as ferrous sulfate and ferrous fumarate. This higher absorption rate means that more iron enters the bloodstream where it can be used by the body, ensuring optimal benefits.

The superior absorption of iron bisglycinate can be attributed to its unique chemical structure. Unlike other forms of iron, bisglycinate is chelated, meaning the iron is bound to an amino acid (glycine). This chelation allows it to pass through the stomach and reach the small intestine without interacting negatively with other components of the diet. As a result, iron bisglycinate evades the common pitfalls that reduce the absorption of other iron forms.

Fewer Side Effects

A notable disadvantage of many iron supplements is the adverse gastrointestinal effects they can induce. Common complaints associated with iron supplementation include stomach cramps, constipation, and nausea. These side effects can discourage individuals from continuing their supplementation, leading to decreased compliance and worsening iron deficiencies.

However, iron bisglycinate offers a solution. Its chelated structure ensures that it is gentle on the stomach. Studies have shown that individuals taking iron bisglycinate experience fewer side effects compared to those taking other forms of iron. This higher tolerance can lead to better adherence to supplementation, ensuring that individuals reap the full benefits of their iron intake.

Comparing to Other Forms

To truly understand the advantages of iron bisglycinate, it helps to compare it to other popular forms of iron:

  1. Ferrous Sulfate: Often prescribed due to its high elemental iron content, ferrous sulfate, unfortunately, has poor solubility in the upper intestine, leading to low absorption and common gastrointestinal side effects.

  2. Ferrous Fumarate: Although it is more soluble than ferrous sulfate, it still lags behind in absorption when compared to iron bisglycinate and can lead to similar side effects.

  3. Ferric Citrate & Ferric EDTA: These are not as commonly used due to concerns about lower absorption rates and potential interactions with other medications.

In contrast, iron bisglycinate boasts high absorption rates while being gentle on the digestive system, making it a preferable choice for many.


Iron deficiency is a global concern, with millions affected by conditions like iron-deficiency anemia. Choosing the right iron supplement is crucial in addressing this deficiency effectively. Iron bisglycinate, with its superior absorption and reduced side effects, stands out as an optimal choice. While every individual's needs are unique, and it's essential to consult with a healthcare provider, the data and research studies tilt the balance in favor of iron bisglycinate as the preferred choice for iron supplementation.

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